Syndecan-4 in Tumor Cell Motility

Syndecan-4 (SDC4) is a ubiquitously expressed, transmembrane proteoglycan bearing heparan sulfate chains. SDC4 involved in numerous inside-out and outside-in signaling processes, such as binding sequestration of growth factors extracellular matrix components, regulation the activity small GTPase Rac1, protein kinase C-alpha, level intracellular calcium, or phosphorylation focal adhesion kinase. The ability this to link actin cytoskeleton enables contribute biological functions like cell migration, proliferation, cytokinesis, cellular polarity, mechanotransduction. multiple roles tumor pathogenesis progression has already been demonstrated; therefore, expression was investigated several types. influences by regulating proliferation well migration affecting cell-matrix pathways. Here, we summarize general role motility.